Researchers have used gene therapy to restore colour vision in two adult monkeys that have been unable to distinguish between red and green hues since birth raising the hope of curing colour blindness and other visual disorders in humans.
"This is a truly amazing study," says András Komáromy, a vision researcher and veterinary ophthalmologist at the University of Pennsylvania in Philadelphia, who was not involved in the research. "If we can target gene expression specifically to cones [in humans] then this has a tremendous implication."
About 1 in 12 men lack either the red- or the green-sensitive photoreceptor proteins that are normally present in the colour-sensing cells, or cones, of the retina, and so have redgreen colour blindness. A similar condition affects all male squirrel monkeys (Saimiri sciureus), which naturally see the world in just two tones. The colour blindness in the monkeys arises because full colour vision requires two versions of the opsin gene, which is carried on the X chromosome. One version codes for a red-detecting photoreceptor, the other for a green-detecting photoreceptor. As male monkeys have only one X chromosome, they carry only one version of the gene and are inevitably redgreen colour blind. A similar deficiency accounts for the most common form of dichromatic color blindness in humans. Fewer female monkeys suffer from the condition as they have two X chromosomes, and often carry both versions of the opsin gene.
Lees meer:
http://www.nature.com/news/2009/090916/ful...s.2009.921.html
En omdat Nature news na een tijdje niet meer beschikbaar is zonder abonnement:
http://www.neitzvision.com/content/genetherapy.html
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Colour blindness corrected by gene therapy
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Colour blindness corrected by gene therapy
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