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Ogen kunnen voortekenen van alzheimer verraden


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#1

Lathander

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Geplaatst op 15 januari 2010 - 12:21

http://www.nu.nl/wetenschap/2162920/


AMSTERDAM – De eerste voortekenen van Alzheimer kunnen in de toekomst mogelijk worden opgespoord met een oogtest. Dat beweren Britse wetenschappers na een experiment met muizen

EDIT: nog meer nieuws over identificate van Alzheimer

Proteins That Might Contribute to Memory Loss and Alzheimer's Disease Identified

ScienceDaily (Jan. 15, 2010) — A scientific group led by the Translational Genomics Research Institute (TGen) have identified three kinases, or proteins, that dismantle connections within brain cells, which may lead to memory loss associated with Alzheimer's disease

Veranderd door Evil Lathander, 15 januari 2010 - 17:08

"Invisible Pink Unicorns are beings of great spiritual power. We know this because they are capable of being invisible and pink at the same time. Like all religions, the Faith of the Invisible Pink Unicorns is based upon both logic and faith. We have faith that they are pink; we logically know that they are invisible because we can't see them."


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#2

Dido

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Geplaatst op 15 januari 2010 - 13:35

En gisteren las ik toevallig ook dat een verminderde reuk het eerste teken kan zijn van Alzheimer.

A study published in the January 13, 2010 issue of the Journal of Neuroscience links a loss of smell function in Alzheimer's disease (AD) model animals with amyloid (protein) accumulation in the brain, a distinguishing hallmark of Alzheimer's disease. Research conducted by NYU Langone Medical Center suggests that olfactory dysfunction, a common symptom of AD, may serve as an early diagnostic tool for the disease.
The formation of amyloid plaques and neurofibrillary tangles are believed to contribute to the degradation of the neurons in the brain and the subsequent symptoms of AD. In this newly published study, NYU Langone scientists used genetically engineered mice, which developed amyloids in their brains, reflecting a progressive Alzheimer's disease pathology similar to humans. They found that Alzheimer's disease amyloid pathology occurs first in a region of the mouse brain responsible for smelling -- which is directly above their noses. This pathology also coincided with the animals having abnormal abilities to smell. The mice with a high concentration of amyloid in their brains had to sniff odors longer to "learn" them than mice with less amyloid. They also had problems differentiating between odors....

uit: NYU Langone Medical Center / New York University School of Medicine(2010, January 13). Loss of smell function may predict early onset ofAlzheimer's disease. ScienceDaily.
Als we nu nog een therapie/ behandeling voor deze dramatische ziekte vinden, dan kunnen we deze mensen, met de eerste signalen van de ziekte, tenminste iets mťťr bieden dan enkel het feit dŗt ze vermoedelijk (?) Alzheimer zullen krijgen...

Dido
Ik ben niet jong genoeg om alles te weten...
-Oscar Wilde-

#3

ypsilon

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Geplaatst op 15 januari 2010 - 15:28

Een andere test met behoorlijk goede resultaten is trouwens ook ooggerelateerd: klassieke conditionering van de knipperreflex (bij blazen in de ogen). Iemand die daar wat over heeft?

#4

Dido

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Geplaatst op 15 januari 2010 - 16:59

Een andere test met behoorlijk goede resultaten is trouwens ook ooggerelateerd: klassieke conditionering van de knipperreflex (bij blazen in de ogen). Iemand die daar wat over heeft?

Da's er ťťntje, denk ik (mťt full text, voor als je er zin in hebt :eusa_whistle: )...
Eyeblink conditioning discriminates Alzheimer's patients from non-demented aged (Clinical Neuroscience and Neuropathology, sept. 1990)

Classical conditioning of the eyeblink response in rabbits is a model system useful in research on the neurobiology of learning, memory and aging, and it has implications for Alzheimer's disease (AD). The hippocampus and cerebellum are brain structures of demonstrated involvement in eyeblink conditioning. AD profoundly impairs the septo-hippocampal cholinergic system; thus, AD patients should show greater impairment of eyeblink conditioning than non-demented, age-matched subjects. Twenty probable AD patients and 20 non-demented age-matched subjects were classically conditioned in the delay paradigm. While control subjects showed clear evidence of acquisition (31.54% conditioned responses [CRs]), probable AD patients showed significant impairment (10.77% CRs). Eyeblink classical conditioning may be useful for AD research and assessment.

Of anders, dit artikel (enkel een abstract):

One of the primary features of Alzheimer's disease (AD) is a disorder of memory. Although considerable effort has been devoted to characterizing this memory disorder, simple forms of memory such as classical (Pavlovian) conditioning have not been studied. The prevailing view has been that these simple forms of memory are not affected in AD. These forms of memory, however, may be of particular interest because they are beginning to be well understood at the neurobiological level. Because of this, when memory disorders are detected, it may be possible to specify their neurobiological substrate. We now report that classical conditioning of the eyeblink response is disrupted in AD patients compared to age-matched controls. This deficit in conditioning is not due to nonassociative factors such as changes in sensitivity to stimuli or disruption of the motor response. The results are considered in terms of using simple forms of memory to help generate hypotheses regarding the neurobiology of age-related memory disorders.

uit: Neurobiol Aging. 1991 Jul-Aug;12(4):283-7. Disruption of classical conditioning in patients with Alzheimer's disease (Solomon PR et all)

Dido

Veranderd door Dido, 15 januari 2010 - 17:06

Ik ben niet jong genoeg om alles te weten...
-Oscar Wilde-





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