Een andere test met behoorlijk goede resultaten is trouwens ook ooggerelateerd: klassieke conditionering van de knipperreflex (bij blazen in de ogen). Iemand die daar wat over heeft?
Da's er ééntje, denk ik (mét full text, voor als je er zin in hebt
)...Eyeblink conditioning discriminates Alzheimer's patients from non-demented aged (Clinical Neuroscience and Neuropathology, sept. 1990)
Classical conditioning of the eyeblink response in rabbits is a model system useful in research on the neurobiology of learning, memory and aging, and it has implications for Alzheimer's disease (AD). The hippocampus and cerebellum are brain structures of demonstrated involvement in eyeblink conditioning. AD profoundly impairs the septo-hippocampal cholinergic system; thus, AD patients should show greater impairment of eyeblink conditioning than non-demented, age-matched subjects. Twenty probable AD patients and 20 non-demented age-matched subjects were classically conditioned in the delay paradigm. While control subjects showed clear evidence of acquisition (31.54% conditioned responses [CRs]), probable AD patients showed significant impairment (10.77% CRs). Eyeblink classical conditioning may be useful for AD research and assessment.
Of anders, dit artikel (enkel een abstract):
One of the primary features of Alzheimer's disease (AD) is a disorder of memory. Although considerable effort has been devoted to characterizing this memory disorder, simple forms of memory such as classical (Pavlovian) conditioning have not been studied. The prevailing view has been that these simple forms of memory are not affected in AD. These forms of memory, however, may be of particular interest because they are beginning to be well understood at the neurobiological level. Because of this, when memory disorders are detected, it may be possible to specify their neurobiological substrate. We now report that classical conditioning of the eyeblink response is disrupted in AD patients compared to age-matched controls. This deficit in conditioning is not due to nonassociative factors such as changes in sensitivity to stimuli or disruption of the motor response. The results are considered in terms of using simple forms of memory to help generate hypotheses regarding the neurobiology of age-related memory disorders.
uit: Neurobiol Aging. 1991 Jul-Aug;12(4):283-7. Disruption of classical conditioning in patients with Alzheimer's disease (Solomon PR et all)
Veranderd door Dido, 15 januari 2010 - 17:06
Ik ben niet jong genoeg om alles te weten...