Common Cause of All Forms of Amyotrophic Lateral Sclerosis (ALS) Discovered
The underlying disease process of amyotrophic lateral sclerosis (ALS and Lou Gehrig's disease), a fatal neurodegenerative disease that paralyzes its victims, has long eluded scientists and prevented development of effective therapies. Scientists weren't even sure all its forms actually converged into a common disease process.
But a new Northwestern Medicine study for the first time has identified a common cause of all forms of ALS.
The basis of the disorder is a broken down protein recycling system in the neurons of the spinal cord and the brain. Optimal functioning of the neurons relies on efficient recycling of the protein building blocks in the cells. In ALS, that recycling system is broken. The cell can't repair or maintain itself and becomes severely damaged.
The discovery by Northwestern University Feinberg School of Medicine researchers, published in the journal Nature, provides a common target for drug therapy and shows that all types of ALS are, indeed, tributaries, pouring into a common river of cellular incompetence.
"This opens up a whole new field for finding an effective treatment for ALS," said senior author Teepu Siddique, M.D., the Les Turner ALS Foundation/Herbert C. Wenske Professor of the Davee Department of Neurology and Clinical Neurosciences at Northwestern's Feinberg School and a neurologist at Northwestern Memorial Hospital. "We can now test for drugs that would regulate this protein pathway or optimize it, so it functions as it should in a normal state."
Lees verder: http://www.sciencedaily.com/releases/2011/...10821141115.htm
Bron: Northwestern University - AAAS
Laatste berichten
- 23:58 speciale rel. theorie 4
- 22:24 Ervaringen met "herontdekkingen" 3
- 20:37 Casus uit de praktijk: positief test THC 16
- 17:43 Vreemde stank in huis 11
- 16:38 3 vragen over mijn rooskleurige r.berekening H2netGekoppeldeHBrflowbatterij.
- 10:05 Interpretatie reactie-energie 3
- 17 apr Logistic equation (Pierre Verhulst,Belgian Mathematician) 5
- 16 apr vB 9
- 15 apr Kunnen quantum Zonnecellen 190% quantum efficiënt zijn 1
- 15 apr Python: sockets sluiten 4
- 14 apr Een eenvoudige logische redenering waarom tijd niet kan bestaan 'daarbuiten' 6
- 14 apr Hoe kun je op quantumwijze getallen vinden in een rij die kleiner zijn dan getal k 3
- 13 apr Rotatie van het heelal 22
- 13 apr Documentenverdwijnen uit onedrive 1
- 12 apr Behoud van impulsmoment en energie 5
- 12 apr INLOG STORING / TIPS 4
- 09 apr [natuurkunde] systeemgrafen 1
- 05 apr afbuiging licht rond zware objecten via grondbeginselen relativiteitstheorie 490
- 05 apr Ongepaste reclame 179
- 04 apr Gegevens wissen mobiel 6
Nieuwsberichten
- 04 mar Een nieuw soort magnetisme: altermagnetisme
- 31 okt AI kan via stem diabetes vaststellen 11
- 21 okt Einstein krijgt wéér gelijk 45
- 07 feb witter dan wit 20
- 19 jun irrigatie en de aardas
Common cause of all forms of amyotrophic lateral sclerosis discovered
Moderator: Astro
- Berichten: 10.179
Common cause of all forms of amyotrophic lateral sclerosis discovered
Zoek je graag naar het meest interessante wetenschapsnieuws? Wij zoeken nog een vrijwilliger voor ons nieuwspostteam.