Breakthrough in regulating fat metabolism

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Bericht 10-12-'11, 10:06

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Breakthrough in regulating fat metabolism

Breakthrough in Regulating Fat Metabolism


Scientists at Warwick Medical School have made an important discovery about the mechanism controlling the body's 'fat switch', shedding new light on our understanding of how proteins regulate appetite control and insulin secretion.


The enzyme known as 'Carnitine palmitoyltransferase 1A' (CPT1) has a switch which is thrown depending on the composition and curvature of its cellular membrane. This is the first time such a mechanism has been described and may possibly be unique, reflecting the importance of this protein to cellular function.

CPT1 is the key protein that regulates fatty acid oxidation in the liver and is critical for metabolism. Its activity determines whether individuals suffer from fatty liver in one extreme or ketosis in the other.


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Gebaseerd op een studie van de University of Warwick.
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