Metabole activatie

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Bericht 01-11-'13, 13:58

trude

Berichten: 4

Metabole activatie

Hoi,

Veel carcinogenen moeten in ons lichaam eerst metabole activatie ondergaan voordat ze schadelijk kunnen zijn. Wat is metabole activatie precies?

Bedankt!

Trude
Omhoog

Bericht 02-11-'13, 14:54

Kravitz

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Re: Metabole activatie

Met onderstaand artikel kan je wel iets waarschijnlijk:
Most chemical carcinogens are not active in themselves but require bioactivation to electrophiles that bind covalently to DNA and often act by producing mutations. In recent years it has beem realized that mutations can be important at many stages of carcinogenesis. A variety of different enzymes are involved in bioactivation reactions, which include oxidation, reduction, thiol conjugation, acetyl transfer, sulfur transfer, methyl transfer, glucuronosyl transfer, and epoxide hydrolysis. These processes often occur in concert with a single carcinogen. Humans vary considerably in activities of these enzymes and this variation may contribute to differences in risk.
doi: http://dx.doi.org/10...7258(92)90050-A
"Success is the ability to go from one failure to another with no loss of enthusiasm" - Winston Churchill
Omhoog

Bericht 02-11-'13, 19:37

trude

Berichten: 4

Re: Metabole activatie

Hoi,

Bedankt, ik weet genoeg :)
Omhoog
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