DNA polymerases, which produce copies of DNA molecules, are enzymes that have evolved for millennia, and there has been little success in getting them to work on artificial DNA in living cells. For the development of engineered genetics, it would be advantageous to find ways to hijack a cell’s enzymes for the replication of unnatural DNA. In working towards that goal, Eric Kool and his colleagues from Stanford University and the Massachusetts Institute of Technology managed to insert and replicate artificial DNA in E. coli cells. This first successful example of bypassing the natural cellular replication machinery was published as an advanced article in the Angewandte Chemie International Edition.
Bekijk het gehele bericht
Veranderd door Klintersaas, 22 mei 2009 - 16:28