Als je 20 zulke kinderen ziet, zal er gemiddeld genomen eentje daarvan Schizofrenie krijgen. Dit terwijl de prevalentie van Schizofrenie in de algemene populatie +/- 1% is. Het gaat dus zeker (nog) niet om een perfecte voorspeller van Schizofrenie, maar toch zeggen deze cognitieve problemen al iets...
uit: Duke University (2010, January 21). Team finds childhood clues to adult schizophrenia. ScienceDaily.Years before adults develop schizophrenia, there is a pattern of cognitive difficulties they experience as children, including problems with verbal reasoning, working memory, attention and processing speed.
Drawing on a long-term study of more than 1,000 New Zealanders born from 1972 to 1973, a team led by Duke researchers has found a consistent pattern of developmental difficulties that first appeared when adult study subjects with schizophrenia were 7 years old.
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"These kids are lagging behind to begin with and they continue to fall behind," said study co-author Richard Keefe, director of Duke's Schizophrenia Research Group. Their verbal skills are initially poor, and then they develop other problems along the way, including difficulties with memory and verbal processing, key factors in learning.
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Two patterns emerged: The children who developed adult schizophrenia had early deficits in verbal and visual learning, reasoning and conceptualization that remained with them as they grew. They also showed slower development than their peers in processing speed, attention, visual-spatial problem-solving and working memory. The data argues against one theory that schizophrenia stems from a deterioration of cognitive abilities. The minds of these children grew, they just didn't grow as well.
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It's possible that a child who struggles to make sense of the world becomes more socially isolated or more delusional, Caspi said. "How does a brain that's ill-equipped to deal with novel sensations deal with the stresses of adolescence?"
With this new evidence in hand, it may be tempting to try to somehow prevent schizophrenia by treating younger patients with anti-psychotic medications, said Keefe. But you'd be treating 20 percent of kids to prevent the 1 percent occurrence of schizophrenia, meaning 19 patients were treated unnecessarily, risking side effects.
"Of course, eventually we hope we'd be able to intervene, maybe even without drugs," Keefe said. Knowing more about the early clues to schizophrenia could lead to better studies of possible cognitive interventions, he said.
The findings suggest that adult psychosis doesn't just emerge fully-formed. It probably comes from a developmental process. "What we think of as adult psychiatric disorders have their roots much earlier in life," Caspi said...
abstract van de studie: Reichenberg et al. Static and Dynamic Cognitive Deficits in Childhood Preceding Adult Schizophrenia: A 30-Year Study. American Journal of Psychiatry, 2010
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