Childhood stress such as abuse or emotional neglect can result in structural brain changes

Lathander

http://www.sciencedaily.com/releases/2010/...00225122705.htm

ScienceDaily (Feb. 26, 2010) New research using magnetic resonance imaging (MRI) shows that childhood stress such as abuse or emotional neglect, in particular when combined with genetic factors, can result in structural brain changes, rendering these people more vulnerable to developing depression

dragonitor

Dat vermoeden hadden we al 300 jaar, nu is het bewezen.

anusthesist

Wat een sof;

The study was conducted on a total of 24 patients (aged 18-65 years) being treated as inpatients for major depression. They were investigated with high-resolution structural MRI and childhood stress asessments. Special analysis programmes were used to measure brain regions. These patients were compared with 27 healthy control subjects from the local community who were matched for age and gender.

Ik mis dan het stukje: 'het bleek dat...'

De resultaten zijn na de conclusie de belangrijkste gegevens. In plaats daarvan krijgen we in vogelvlucht de methode.

Dido

anusthesist schreef:Ik mis dan het stukje: 'het bleek dat...'

De resultaten zijn na de conclusie de belangrijkste gegevens. In plaats daarvan krijgen we in vogelvlucht de methode.

Terechte opmerking, vind ik ook... Ik had graag geweten welke veranderingen er precies werden vastgesteld, maar dat vind je er niet in terug. Ik heb nog even verder gezocht (andere artikels over die studie), maar ook dat leverde niets op.

Dido

Dido

De abstract is ondertussen verschenen en nu wordt het al ietwat interessanter. Blijkbaar ontwikkelden zij die én stressfactoren doormaakten op kinderleeftijd én drager waren van de risico 'S(hort) Serotonine transporter allele' een kleinere hippocampus en een kleinere linker prefrontale cortex. Deze veranderingen lijken inderdaad overeen te komen met veranderingen die men ook merkt bij mensen met een depressieve stoornis.

The underlying neurobiology of major depression (MD) is likely to represent an interaction between genetic susceptibility and environmental factors such as stress. We investigated, in a multimodal high-resolution magnetic resonance imaging (MRI) genetic study, whether reduced hippocampal volumes and other brain alterations are associated with the tri-allelic polymorphism of the serotonin transporter and childhood stress in patients with MD and healthy subjects. Patients with MD and healthy participants were investigated using high-resolution MRI and genotyping for serotonin transporter polymorphism in the promoter region of the serotonin transporter gene (SLC6A4, 5-HTTLPR). Region of interest analysis of the hippocampus, whole-brain voxel-based morphometry (VBM), and assessment of childhood stress were carried out.

Patients carrying the risk S-allele developed smaller hippocampal volumes when they had a history of emotional neglect compared with patients who only had one risk factor (environmental or genetic). In patients, childhood stress also predicted further hippocampal white matter alterations independently from the genotype. Moreover, the left prefrontal cortex was smaller in patients, whereby childhood stress resulted in larger prefrontal volumes in those subjects carrying the non-risk L-allele, suggesting preventive effects. The findings indicate that subjects with both environmental and genetic risk factors are susceptible to stress-related hippocampal changes. Structural brain changes due to stress represent part of the mechanism by which the illness risk and outcome might be genetically mediated.

uit: Holmes, Bogdan et all, Serotonin Transporter Genotype and Action Monitoring Dysfunction: A Possible Substrate Underlying Increased Vulnerability to Depression, Neuropsychopharmacology, 20 Jan. 2010

Dido

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