Eerste varkenshartklep transplantatie
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Eerste varkenshartklep transplantatie
Ik hou mijn profielwerkstuk over xenotransplantatie, maar ik kan nergens vinden wanneer en door wie de eerste transplantatie van een varkenshartklep naar een mens was. Weet iemand dat hier?
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Re: Eerste varkenshartklep transplantatie
Volgens deze site was het in 1965:
Xenografts, the use of tissue from another species, is also possible. Robert Frater in 1961 started using autogenous pericardium to create valves or parts of valves free-hand (Zilla 725). For xenografts to be successful it was important that they found a way to remove the antigens from the tissue so there would be no rejection. This was done by denaturing the proteins with mercurial solutions, freeze-drying or formalin treatment. Shortly the first xenograft aortic valve was ready and successfully implanted in 1965 (725). The next step was taken by two laboratories separately: Robert Carpentier in Paris and Hancock and Nimni in Los Angeles. Both experimented with glutaraldehyde as a preservative for the xenografts and the first aortic porcine valve prepared in this manor was implanted in 1969 (725).
Xenografts, the use of tissue from another species, is also possible. Robert Frater in 1961 started using autogenous pericardium to create valves or parts of valves free-hand (Zilla 725). For xenografts to be successful it was important that they found a way to remove the antigens from the tissue so there would be no rejection. This was done by denaturing the proteins with mercurial solutions, freeze-drying or formalin treatment. Shortly the first xenograft aortic valve was ready and successfully implanted in 1965 (725). The next step was taken by two laboratories separately: Robert Carpentier in Paris and Hancock and Nimni in Los Angeles. Both experimented with glutaraldehyde as a preservative for the xenografts and the first aortic porcine valve prepared in this manor was implanted in 1969 (725).
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